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When one of these events occurs, it disrupts the normal hair growth cycle by pushing more hairs to shift into the resting (telogen) phase, during which they eventually fall out

Three ZO proteins, ZO-1 (220 kDa) (Stevenson et al., 1986), ZO-2 (160 kDa) (Gumbiner et al., 1991), and ZO-3 (130 kDa) (Haskins et al., 1998), have been identified to date

Semax acts primarily via the upregulation of BDNF (Brain-Derived Neurotrophic Factor) and its receptor trkB in the hippocampus